Fibroblast migration after myocardial infarction is regulated by transient SPARC expression
نویسندگان
چکیده
منابع مشابه
Cxcr4 expression is associated with time–course permanent and temporary myocardial infarction in rats
Objective(s): Experimental myocardial infarction triggers secretion of Stromal cell-derived factor1 and lead to increase in the expression of its receptor "CXCR4" on the surface of various cells. The aim of this study was to evaluate the expression pattern of CXCR4 in peripheral blood cells following time-course permanent and temporary ischemia in rats. Materials and Methods: Fourteen male Wist...
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A 69-year-old woman was admitted to our hospital because of weight loss and progressively worsening dyspnoea. Her previous medical history was unremarkable. She was admitted to the internal medicine department. A cardiologist was consulted because of atrial fibrillation with rapid ventricular response and an enlarged cardiac silhouette on her chest Xray. On physical examination her blood pressu...
متن کاملSenescent Cardiac Fibroblast Is Critical for Cardiac Fibrosis after Myocardial Infarction
Senescence is a recognized mechanism of cardiovascular diseases; however, its contribution to myocardial fibrosis and rupture after infarction and the underlying mechanisms remain unclear. Here we showed that senescent cardiac fibroblasts markedly accumulated in heart after myocardial infarction. The expression of key senescence regulators, especially p53, was significantly up-regulated in the ...
متن کاملMatricellular protein SPARC/osteonectin expression is regulated by DNA methylation in its core promoter region.
BACKGROUND SPARC/osteonectin is an evolutionarily conserved matricellular protein that modulates cell-matrix interaction and cell function. In all vertebrates, SPARC is dynamically expressed during embryogenesis. However, the precise function of SPARC and the regulatory elements required for its expression in particular during early embryogenesis are largely unknown. RESULTS The present study...
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Myristoylated alanine-rich C-kinase substrate (MARCKS) is a ubiquitously expressed substrate of protein kinase C (PKC) that is involved in reorganization of the actin cytoskeleton. We hypothesized that MARCKS is involved in regulation of fibroblast migration and addressed this hypothesis by utilizing a unique reagent developed in this laboratory, the MANS peptide. The MANS peptide is a myristoy...
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ژورنال
عنوان ژورنال: Journal of Molecular Medicine
سال: 2006
ISSN: 0946-2716,1432-1440
DOI: 10.1007/s00109-005-0026-0